Failure of intrathecal antitetanus serum to improve survival in neonatal tetanus.
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منابع مشابه
Failure of intrathecal antitetanus serum to improve survival in neonatal tetanus.
In a prospective study, 161 infants with neonatal tetanus were randomised to receive (a) standard treatment, or (b) standard treatment together with intrathecal equine antitetanus serum, or (c) intrathecal antitetanus serum with systemic betamethasone. There was no difference in survival between the three treatment groups in infants with severe tetanus, but in mild tetanus those who received st...
متن کاملIntrathecal antitetanus serum (horse) with steroid in the treatment of neonatal tetanus.
107 patients with neonatal tetanus were studied and the value of intrathecal antitetanus serum with steroid was noted. The mortality rate in a control group (68%) was significantly higher than that of the test group (37%). Furthermore, a delay in antitetanus serum administration was found to have a strong positive linear correlation with the mortality rate. In fact, the mortality rate for neona...
متن کاملIntrathecal antitetanus serum ( horse ) with steroid in the treatment of neonatal tetanus ARUN
107 patients with neonatal tetanus were studied and the value of intrathecal antitetanus serum with steroid was noted. The mortality rate in a control group (68%) was significantly higher than that ofthe test group (37%). Furthermore, a delay in antitetanus serum administrationwas found to have a strong positive linear correlation with the mortality rate. In fact, the mortality rate for neonate...
متن کاملIntrathecal vs. intramuscular administration of human antitetanus immunoglobulin or equine tetanus antitoxin in the treatment of tetanus: a meta-analysis.
BACKGROUND Mortality caused by tetanus is still a serious health problem in developing countries. Apart from immunization, early treatment with equine antitetanus serum (ATS) or human tetanus immunoglobulin (TIG) is the real treatment that can avoid death. On pathophysiological grounds intrathecal administration would be preferred because of high concentrations of the antiserum in cerebrospinal...
متن کاملRandomised controlled trial of tetanus treatment with antitetanus immunoglobulin by the intrathecal or intramuscular route.
OBJECTIVE To evaluate the effect of intrathecal therapy with human antitetanus immunoglobulin on clinical progression of and mortality from tetanus. DESIGN Randomised controlled trial. SETTING Intensive care unit of a university hospital, Pernambuco, Brazil. PARTICIPANTS 120 patients with tetanus allocated to antitetanus immunoglobulin by either the intrathecal and intramuscular route (n ...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1983
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.58.4.276